Application | Comment | Organism |
---|---|---|
diagnostics | the mouse monoclonal antibody for AKR1C3, 10B10, is highly specific and sensitive for detecting AKR1C3 expression including patient samples. The proper detection of AKR1C3 expression is critical for therapeutics targeting AKR1C3, 10B10 will be a valuable tool in clinic for AKR1C3 precision therapy. 10B10 is specific to AKR1C3 protein and has a very low cross-activity against other AKR1 proteins | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P42330 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
AKR1C3 | - |
Homo sapiens |
type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | expression is relatively low in most tissues and high in prostate and mammary glands in regulating androgen and estrogen levels. In many cancers, overexpression of AKR1C3 is observed | up |
General Information | Comment | Organism |
---|---|---|
metabolism | besides as a biomarker in cancer, AKR1C3 is important in the reduction of steroids and prostaglandins, and function as part of a chemical barrier to defend the body from intrusion of toxic chemicals | Homo sapiens |